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Paulo Breno Noronha Liberalesso's research while affiliated with Hospital Pequeno Príncipe and other places
Paulo Breno Noronha Liberalesso's research works | Hospital Pequeno Príncipe, Curitiba and other places
Paulo Breno Noronha Liberalesso's research works | Hospital Pequeno Príncipe, Curitiba and other places
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Preclinical evaluation of the selective small-molecule UBA1 inhibitor, TAK-243, in acute myeloid leukemia | Leukemia
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Paulo Breno Noronha Liberalesso's research works | Hospital Pequeno Príncipe, Curitiba and other places
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Paulo Breno Noronha Liberalesso's research works | Hospital Pequeno Príncipe, Curitiba and other places
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TAK-243 preferentially binds UBA1 and reduces levels of global protein ubiquitylation in AML cell lines and primary cells. a OCI-AML2 cells were treated ...
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Y583C and A580S UBA1 mutations confer resistance to TAK-243 in AML cells. a, b Sensitive and resistant OCI-AML2IC90 and OCI-AML2SW cell lines were treated ...
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TAK-243 inhibits DNA double-strand break repair in AML cells. a, b OCI-AML2 cells were treated with increasing concentrations of TAK-243 for increasing ...
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Fagan's nomogram showing the posterior probability for a positive MTb qPCR in cerebrospinal fluid and for
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TAK-243 induces proteotoxic stress in AML cells. a OCI-AML2 cells were treated with increasing concentrations of TAK-243 for increasing times.
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TAK-243 reduces the leukemic burden in mouse models of AML, and preferentially binds and inhibits UBA1 in AML cells in vivo. a OCI-AML2 cells (1 × 106) were ...
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Briefly, 2.5 µL of extraction product was added to 22.5 µL of a PCR mix (Bioron, Ludwigshafe, GE) containing 2.5 mM dNTPs, 1.25 U of Taq DNA Polymerase, ...
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... one being GII specific and the third exhibiting no genogroup specificity. Briefly, 2.5 µL of cDNA was added to 22.5 µL of a PCR mix (Bioron) ...
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Positivity rate of MTb qPCR in cerebrospinal fluid in the different groups for Tb meningitis diagnosis
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Genomic landscape of paediatric adrenocortical tumours | Nature Communications